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Ephedra Research II: Clinical Trials With Ephedra

** Most of the studies and documents that follow were made available by the House Committee on Energy and Commerce during the course of hearings on Ephedra in June 2003. The format in which these studies are recorded replicates the exibit nomenclature and identification used by the Committee on Energy and Commerce.

C N Boozer, J A Nasser, S B Heymsfield, V Wang, G Chen, J L Solomon. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. International Journal of Obesity 25, 316 - 324 (22 Feb 2001)
Made available by the House Committee on Energy and Commerce (July 2003)
Exhibit 99 – Study by Carol Boozer. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. pdf icon Publ'd 2001

C N Boozer, P A Daly, P Homel, J L Solomon, D Blanchard, J A Nasser, R Strauss, T Meredith. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. International Journal of Obesity 26, 593 - 604 (25 Apr 2002)


R L Atkinson, International Journal of Obesity 26, 589 (25 Apr 2002) Editorial

A G Dulloo, International Journal ofObesity 26, 590 – 592 (25 Apr 2002) Guest Editorial

D Kalman, T Incledon, I Gaunaurd, H Schwartz, D Krieger. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra caffeine weight loss product in healthy overweight adults. International Journal of Obesity 26, 1363 – 1366 (01 Oct 2002)


Letter to editor of the International Journal of Obesity from Doug Kalman pdf icon;
States that since the publication of their study, he and his research team have come to new conclusions regarding the adverse events experienced by the study subjects. (13 May 2003)
Letter of rejection letter to Doug Kalman pdf icon from Obesity Research, stating that the journal will not publish his study. Includes reviewers criticisms. (18 January 2000)

Cytodyne Technology – Documents made available by the House Committee on Energy and Commerce (July 2003)
Study on Ephedra by Dr Carlon Colker pdf icon 10 April 2000
Full citation for above: Kalman DS, Colker CM, Q Shi, MA Swain. Effects of a weight loss aid in health overweight adults: double blind placebo controlled clinical trial. Current Therapeutic Research 61 199-205 (April 2000)
Abstract of study on ephedra by Colker pdf icon (undated)

CanTox Report Safety Assessment and Determination of a Tolerable Upper Limit For Ephedra. pdf icon (Prepared for The Council For Responsible Nutrition by CANTOX Health Science International, 2000-12-19)

Carlon M. Colker, M.D., Georgeann C. Torina, Melissa A, Swain, Douglas S. Kalman. Double-Blind, Placebo Controlled Evaluation of the Safety and Efficacy of Ephedra, Caffeine, and Salicin for Short Term Weight Reduction in Overweight Subjects. pdf icon American Society of Exercise Physiologists, 2nd Annual Meeting, 1999 – Abstract # 26

W. Jeffery Armstrong, Patrick Johnson, and Simone Duhme. The Effect Of Commercial Thermogenic Weight Loss Supplement On Body Composition And Energy Expenditure In Obese Adults. pdf icon JEPonline. 2001; 4 (2): 28-34.

Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects. Evidence Report/Technology Assessment No. 76. Shekelle P, Morton, S., Maglione M, et al. (Prepared by Southern California Evidence-based Practice Center, RAND, under Contract No 290-97-0001, Task Order No. 9). AHRQ Publication No. 03-E022. Rockville, MD: Agency for Healthcare Research and Quality. February 2003

F Greenway The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent
Obesity Reviews 2 199-212 (2001) pdf icon

Ephedra Information Council

Who or what is the Ephedra Education Council?

The Ephedra Education Council (EEC) is an educational organization providing factual information on ephedra dietary supplements to media, government, health professionals and the public. The EEC is supported by leading dietary supplement manufacturers and distributors that meet the Council's standards for the safe and responsible marketing of ephedra dietary supplements. (Accessed 2003-05-03 at: http://www.ephedrafacts.com/about.html )

Members of the Ephedra Education Council include:

Source: Professional Associations, Charities, and Industry Front Groups, The Center for Science in the Public Interest. Accessed 2004-02-04 at: http://www. cspinet.org/integrity/Integrity_in_Science_organization_list.pdf pdf icon

Also Related

Research Protocol Design: A Randomized, Stratified, Double-Blind, Within-Subject & Between- Subject Study of Herbal Toxicity, Ian D Bier ND, ST & T Consulting, 1995

Bibliography of research on Ephedra – DrugDigest.org


Last Updated: 2005-02-26

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