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Andrew J. Wakefield and Research with Autistic Children

Posted on 2007-08-01; we apologize for any inconvenience while we work on this page.

Clinical Trial Documents and REC Correspondence

Protocol No. 172-96, A new syndrome: enteritis and disintegrative disorder following measles and measles/rubella vaccination. 1996-09-16. Royal Free Hospital (Principal investigator Andrew Wakefield): http://www.circare.org/consents/wakefield_protocol_19960916.pdf (1)

Consent Form, A new syndrome: enteritis and disintegrative disorder following measles and measles/rubella vaccination. 1996-09-16: http://www.circare.org/consents/wakefield_consent_19960916.pdf

Protocol Pro Forma, A new syndrome: enteritis and disintegrative disorder following measles and measles/rubella vaccination. 1996-08-06: http://www.circare.org/autism/wakefield_proforma_19960608.pdf (2)

Epstein O. Independent review of protocol no. 172-96. Undated: http://www.circare.org/autism/epstein_wakefield.pdf (3)

Walker-Smith J. Correspondence to M. Pegg re: protocol no. 172-96. 1996-11-11: http://www.circare.org/autism/walker-smith_pegg_19961111.pdf (4)

Pegg M. Correspondence to J. Walker-Smith re: REC approval of protocol no. 172-96 with terms and conditions. 1997-01-07: http://www.circare.org/autism/pegg_walker-smith_19970107.pdf (5)

Walker-Smith J. Correspondence to M. Pegg re: accepting terms and conditions of REC approval of protocol no. 172-96. 1997-01-09: http://www.circare.org/autism/walker-smith_pegg_19970109.pdf

Hull D. Correspondence to A. Zuckerman re: REC approval of protocol no. 172-96. 1998-07-06: http://www.circare.org/autism/hull_zuckerman_19980706.pdf

Walker-Smith J. Correspondence to M. Pegg re: Autism and non-specific colitis and lymphoid nodular hyperplasia. 1998-07-15: http://www.circare.org/autism/walker-smith_pegg_19980715.pdf

Zuckerman A. Correspondence to B. Taylor re: REC approval of protocol no. 172-96. 1998-07-09: http://www.circare.org/autism/zuckerman_taylor_19980709.pdf

Taylor B. Correspondence to A. Zuckerman re: REC approval of protocol no. 172-96. 1998-07-23: http://www.circare.org/autism/taylor_zuckerman_19980723.pdf

Pegg M. Correspondence to A. Zuckerman re: REC approval of protocol no. 172-96. 1998-07-24: http://www.circare.org/autism/pegg_zuckerman_19980724.pdf

Zuckerman A. Correspondence to D. Hull re: REC approval of protocol no. 172-98. 1998-07-27: http://www.circare.org/autism/zuckerman_hull_19980727.pdf

Protocol No. 22-98, A preliminary open-label study of the effect of oral measles virus-specific dialysable lymphocyte extract transfer factor (DLE-TFmv) in children with autistic enteropathy. 1998-02-02. (Principal Investigator Andrew Wakefield): http://www.circare.org/autism/wakefield_transferfactor_protocol.pdf

Reviewers Comments re: protocol no. 22-98. 1998-10-02: http://www.circare.org/autism/wakefield_tfapplicationcomments_19981002.pdf

Pegg M. Correspondence to J. Walker-Smith re: protocol no. 22-98. 1998-02-26: http://www.circare.org/autism/pegg_walker-smith_19980226.pdf

Walker-Smith J. Correspondence to M. Pegg re: protocol no. 22-98. 1998-03-13: http://www.circare.org/autism/walker-smith_pegg_19980313.pdf

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General Medical Council and Background Information

Fitness to Practise Panels week commencing 09 July 2007. Dr Andrew WAKEFIELD, Professor John WALKER-SMITH, Professor Simon MURCH. General Medical Council Press Release. 2007-07-02. Accessed on 2007-07-08 at: http://www.gmcpressoffice.org.uk/apps/news/latest/detail.php?key=345

Andrew Wakefield, John Walker-Smith, Simon Murch. General Medical Council Fitness to Practice Panel, Charge Sheet. 2007-07-16: http://www.circare.org/consents/wakefield_20070716.pdf

Statutory Instrument 2004 No. 1031 The Medicines for Human Use (Clinical Trials) Regulations 2004 (=Directive 2001/20/EC). Available from http://www.opsi.gov.uk/si/si2004/20041031.htm. Accessibility verified 2006-09-20.

UK Research Policy: International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use Guideline for Good Clinical Practice (ICH): http://www.ich.org/LOB/media/MEDIA482.pdf

UK Ethical Principles in Human Research: World Medical Association Declaration of Helsinki (2004): http://www.wma.net/e/policy/b3.htm

Central Office for Research Ethics Committees (COREC) and United Kingdom Ethics Committee Authority (UKECA): http://www.corec.org.uk/applicants/contacts/recsrecognized.htm

House of Commons Hansard Debates for 15 Mar 2004 (pt 34). MMR Vaccinations and Autism. [Dr. Evan Harris (Oxford, West and Abingdon) (LD)] Accessed on 2007-07-25 at: http://www.publications.parliament.uk/pa/cm200304/cmhansrd/vo040315/debtext/40315-34.htm#40315-34_head1

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MMR Litigation

Mumps, Measles and Rubella (MMR) Vaccines and Measles Rubella (MR) Vaccines Fact Sheet (Dawbarn's Fact Sheet) Rev. 1997-06-03. Accessed on 2007-08-20 at: http://web.archive.org/web/20010718143811/http://www.whale.to/vaccines/dawbarns.html

Dawbarn's MMR Newsletter Spring 1997. Accessed on 2007-08-20 at: http://briandeer.com/wakefield/dawbarns-news.htm

(Dawbarn's) MMR and MR Vaccines Newsletter No. 4. 1996-06-10. Accessed on 2007-08-20 at: http://briandeer.com/wakefield/dawbarns-mailing.htm

Docket of Omnibus Autism Proceeding. United States Court of Federal Claims. Accessed on 2007-07-12 at: http://www.uscfc.uscourts.gov/OSM/AutismDocket.htm

Cedillo v. Secretary of Health and Human Services Case No. 98-916V. Index of digital audio files and transcripts. Accessed on 2007-07-12 at: ftp://autism.uscfc.uscourts.gov/autism/index.html

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Journal Publications

Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998;351:637-641. Accessed on 2007-08-01 at: http://tinyurl.com/3y3fmq

Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S, O'Leary JJ, Berelowitz M, Walker-Smith JA. Enterocolitis in children with developmental disorders. Am J Gastroenterol 2000;95(9):2285-2295. Accessed on 2007-08-01 at: http://tinyurl.com/2o8slj

Furlano RI, Anthony A, Day R, Brown A, McGarvey L, Thomson MA, Davies SE, Berelowitz M, Forbes A, Wakewfield AJ, Walker-Smith AJ, Murch SH. Colonic CD8 and &gamma &delta T-cell infiltration with epithelial damage in children with autism. 2001 Accessed on 2007-08-01 at: http://tinyurl.com/3dfyu8

Bradstreet JJ, El Dahr J, Anthony A, Kartzinel JJ, Wakefield AJ. Detection of measles virus genomic RNA in cerebrospinal fluid of three children with regressive autism: a report of three cases. Journal of American Physicians and Surgeons 2004;9(2):38-45. Accessed on 2007-08-01 at: http://tinyurl.com/3d7p6g

Uhlmann V, Martin CM, Sheils O, Pilkington L, Silva I, Killalea A, Murch SB, Wakefield AJ, O'Leary JJ. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol 2002;55:0-6. Accessed on 2007-08-01 at: http://tinyurl.com/2vacjs

Torrente F, Ashwood P, Day R, Machado N, Furlano RI, Anthony A, Davies SE, Wakefield AJ, Thomson MA, Walker-Smith JA, Murch SH. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psych 2002 Accessed on 2007-08-01 at: http://tinyurl.com/392wny

Wakefield AJ, Ashwood P, Limb K, Anthony A. The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. European Journal of Gastroenterology and Hepatology. 2005;17:627-638. Accessed on 2007-08-01 at: http://tinyurl.com/3yux4x

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U.S. Senate and Congressional Hearings

Serial No. 106-180. Autism: Present Challenges, Future Needs — Why the Increased Rates? Committee on Government Reform and Oversight. House of Representatives. 106th Congress, Second Session. April 6, 2000: http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=106_house_hearings&docid=f:69622.pdf   [File size: 17.3M]
Witnesses: AJ Wakefield, John O'Leary, Walter Spitzer, Bernard Rimland, Michael Goldberg, Mary Megson, John Upledger, Vijendra Singh, Kenneth Curtis, James Smythe, Shelley Reynolds, Jeana Smith, Scott Bono, Wayne Dankner, Cathy Pratt, Deborah Hirtz, Edwin Cook, Jr., Colleen Boyle, Benjamin Schwartz, Paul Offit, Brent Taylor.

Serial No. 107-29. Autism — Why the Increased Rates? A One-Year Update. Committee on Government Reform and Oversight. House of Representatives. 107th Congress, First Session. April 25 and 26, 2001. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:76856.pdf   [File size: 10.5M]
Witnesses: AJ Wakefield, Jeffrey Bradstreet, Cindy Schneider, Jeff Segal, Sharon Humiston, Walter Spitzer, Boyd Haley, David Amaral, Marie McCormick, Christopher McDougle, Elizabeth Miller, Michael Gershon, Owen Rennert, Karen Midthun, Susan Ellenberg, Norman Baylor, Colleen Boyle.

Serial No. 107-121. The Status of Research into Vaccine Safety and Autism. Committee on Government Reform and Oversight. House of Representatives. 107th Congress, Second Session. June 19, 2002. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:82358.pdf   [File size: 16.2M]
Witnesses: AJ Wakefield, Jeffrey Bradstreet, Vera Stejskal, Arthur Krigsman, Frank DeStephano, Robert Chen, Roger Bernier, Stephen Foote, William Egan.

Serial No. 107-153. Vaccines and the Autism Epidemic: Reviewing the Federal Government's Track Record and Charting a Course for the Future. Committee on Government Reform and Oversight. House of Representatives. 107th Congress, Second Session. December 10, 2002. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:84605.pdf   [File size: 15M]
Witnesses: Mark Geier, Walter Spitzer, David Baskin, Karen Midthun, Stephen Foote, Christopher Portier.

Also of Interest

(ground zero: mercury toxicity from dental amalgam morphs into thimerosal-induced autism) Serial No. 106-232. Mercury in Medicine — Are We Taking Unnecessary Risks? Committee on Government Reform and Oversight. House of Representatives. 106th Congress, Second Session. July 18, 2000. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=106_house_hearings&docid=f:72722.pdf   [File size: 32M]
Witnesses: Lyn Redwood, Sallie Bernard, Albert Enyati, Elizabeth Birt, Stephanie Cave, Amy Holmes (statement), Vasken Aposhian, Sharon Humiston, Ramona Trovato, William Egan, Roger Bernier, Marie Bristol-Power.

Serial No. 107-74. The Autism Epidemic — Is the NIH and CDC Response Adequate? Committee on Government Reform and Oversight. House of Representatives. 107th Congress, Second Session. April 18, 2002. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:80356.pdf   [File size: 4.1M]
Witnesses: Lee Grossman, Belinda Lerner, Stephen Shore, Doug Compton, Colleen Boyle, Melinda Wharton, Stephen Foote, Ann Willoughby.

(how de-licensed physician Steven Edelson cures autism: $80,000 for two kids) Serial No. 108-125. The Future Challenges of Autism: A Survey of the Ongoing Initiatives in the Federal Government to Address the Epidemic. Committee on Government Reform and Oversight. House of Representatives. 108th Congress, First Session. November 20, 2003. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=108_house_hearings&docid=f:92727.pdf   [File size: 1.5M]
Witnesses: Ilene Schwartz, Peter van Dyck, Rick Rollens, Steven Edelson, Colleen Pettinati.

(how hyperbaric oxygen treatment and chelation cure autism) Serial No. 108-192. Autism Spectrum Disorders: An Update of Federal Government Initiatives and Revolutionary New Treatment of Neuro-Developmental Diseases. Committee on Government Reform and Oversight. House of Representatives. 108th Congress, Second Session. May 6, 2004. Available from http://a257.g.akamaitech.net/7/257/2422/21oct20031230/www.access.gpo.gov/congress/house/pdf/108hrg/95740.pdf   [File size: 4.6M]
Witnesses: Rashid Buttar, Paul Harch, Kenneth Stoller, Julie Gordon, Shannon Kentiz, Troy Justesen.

Serial No. 108-262. Truth Revealed: New Scientific Discoveries Regarding Mercury in Medicine and Autism. Committee on Government Reform and Oversight. House of Representatives. 108th Congress, Second Session. September 8, 2004. Available from http://a257.g.akamaitech.net/7/257/2422/16feb20051430/www.access.gpo.gov/congress/house/pdf/108hrg/98046.pdf   [File size: 14M]
Witnesses: Richard Deth, Richard Fischer, Lyn Redwood, Mady Hornig, William Egan, Marcel Just, Melinda Warton, Colleen Boyle.

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Media Coverage

Vaccine row parents made to pay for son's diagnosis. Celia Hall. The Telegraph. 1999-06-02. Accessed on 2007-08-20 at: http://www.whale.to/vaccines/mmr13.html

Parents' Fury Over 'Betrayal' of Autistic Boy. Lorraine Fraser. The Telegraph. (Undated) Accessed on 2007-08-20 at: http://www.whale.to/v/mmr44.html

MMR RIP? Robert Sandall. The Sunday Times. 2003-12-14. Accessed on 2007-06-09 at: http://www.timesonline.co.uk/tol/life_and_style/article1042597.ece

BBC News | In Depth | MMR Debate. 2006-06-27. Accessed on 2007-08-20 at: http://news.bbc.co.uk/2/hi/in_depth/health/2002/mmr_debate/default.stm

The MMR-autism scare — our story so far. Brian Deer. Accessed on 2007-07-25 at: http://briandeer.com/mmr/lancet-summary.htm

Brian Deer's MMR Investigation Index. Rev. 2007-07-23. Accessed on 2007-07-25 at: http://briandeer.com/mmr/andrew-wakefield.htm

The MMR-autism theory? There's nothing in it. Michael Fitzpatrick. Spiked Online. 2007-07-04. Accessed on 2007-07-08 at: http://www.spiked-online.com/index.php?/site/article/3562/

Spiked MMR

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Notes

1. Brian Deer. Briandeer.com web site. Accessed on 2007-02-07 at: http://briandeer.com/wakefield/protocol-1996.htm

2. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-11.htm

3. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-8.htm

4. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-9.htm

5. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-10.htm

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Last Updated: 2007-08-20

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