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Updated on 2011-06-03
Protocol No. 172-96, A new syndrome: enteritis and disintegrative disorder following measles and measles/rubella vaccination. 1996-09-16. Royal Free Hospital (Principal investigator Andrew Wakefield): http://www.circare.org/consents/wakefield_protocol_19960916.pdf (1)
Consent Form, A new syndrome: enteritis and disintegrative disorder following measles and measles/rubella vaccination. 1996-09-16: http://www.circare.org/consents/wakefield_consent_19960916.pdf
Protocol Pro Forma, A new syndrome: enteritis and disintegrative disorder following measles and measles/rubella vaccination. 1996-08-06: http://www.circare.org/autism/wakefield_proforma_19960608.pdf (2)
Epstein O. Independent review of protocol no. 172-96. Undated: http://www.circare.org/autism/epstein_wakefield.pdf (3)
Walker-Smith J. Correspondence to M. Pegg re: protocol no. 172-96. 1996-11-11: http://www.circare.org/autism/walker-smith_pegg_19961111.pdf (4)
Pegg M. Correspondence to J. Walker-Smith re: REC approval of protocol no. 172-96 with terms and conditions. 1997-01-07: http://www.circare.org/autism/pegg_walker-smith_19970107.pdf (5)
Walker-Smith J. Correspondence to M. Pegg re: accepting terms and conditions of REC approval of protocol no. 172-96. 1997-01-09: http://www.circare.org/autism/walker-smith_pegg_19970109.pdf
Hull D. Correspondence to A. Zuckerman re: REC approval of protocol no. 172-96. 1998-07-06: http://www.circare.org/autism/hull_zuckerman_19980706.pdf
Walker-Smith J. Correspondence to M. Pegg re: Autism and non-specific colitis and lymphoid nodular hyperplasia. 1998-07-15: http://www.circare.org/autism/walker-smith_pegg_19980715.pdf
Zuckerman A. Correspondence to B. Taylor re: REC approval of protocol no. 172-96. 1998-07-09: http://www.circare.org/autism/zuckerman_taylor_19980709.pdf
Taylor B. Correspondence to A. Zuckerman re: REC approval of protocol no. 172-96. 1998-07-23: http://www.circare.org/autism/taylor_zuckerman_19980723.pdf
Pegg M. Correspondence to A. Zuckerman re: REC approval of protocol no. 172-96. 1998-07-24: http://www.circare.org/autism/pegg_zuckerman_19980724.pdf
Zuckerman A. Correspondence to D. Hull re: REC approval of protocol no. 172-98. 1998-07-27: http://www.circare.org/autism/zuckerman_hull_19980727.pdf
Protocol No. 22-98, A preliminary open-label study of the effect of oral measles virus-specific dialysable lymphocyte extract transfer factor (DLE-TFmv) in children with autistic enteropathy. 1998-02-02. (Principal Investigator Andrew Wakefield): http://www.circare.org/autism/wakefield_transferfactor_protocol.pdf
Reviewers Comments re: protocol no. 22-98. 1998-10-02: http://www.circare.org/autism/wakefield_tfapplicationcomments_19981002.pdf
Pegg M. Correspondence to J. Walker-Smith re: protocol no. 22-98. 1998-02-26: http://www.circare.org/autism/pegg_walker-smith_19980226.pdf
Walker-Smith J. Correspondence to M. Pegg re: protocol no. 22-98. 1998-03-13: http://www.circare.org/autism/walker-smith_pegg_19980313.pdf
Secrets of the MMR Scare, The BMJ Series. Brian Deer 01-2011: http://briandeer.com/solved/bmj-secrets-series.htm
Solved – the Riddle of MMR. Brian Deer. 2010- : http://briandeer.com/solved/solved.htm
General Medical Council Hearing Transcripts (Drs. Murch, Walker-Smith, and Wakefield) : https://docs.google.com/leaf?id=0B9Ek8hRNlhrbNTk4MWI5YjktMDU3MS00MWU1LWFiZjQtZjA3MzI0ZDM0NTBl&hl=en (file size = 10 MB; Word files by hearing day (+150 days), ca. 10,000 pages)
Andrew Wakefield case highlights the importance of ethics in science. Sarah Boseley. The Guardian 2010-05-24: http://www.guardian.co.uk/society/2010/may/24/andrew-wakefield-analysis-ethics-science
MMR row doctor Andrew Wakefield struck off register. James Meikle and Sarah Boseley. The Guardian 2010-05-24: http://www.guardian.co.uk/society/2010/may/24/mmr-doctor-andrew-wakefield-struck-off
Professor Simon Murch: Determination on Serious Professional Misconduct 24 May 2010: http://www.circare.org/autism/Professor_MURCH_determination_32597633.pdf
Dr. John Walker-Smith: Determination on Serious Professional Misconduct 24 May 2010: http://www.circare.org/autism/Professor_Walker_Smith_SPM_32595970.pdf (NB: Professor Walker-Smith has appealed)
Dr. Andrew Wakefield: Determination on Serious Professional Misconduct 24 May 2010: http://www.circare.org/autism/Wakefield_SPM_and_SANCTION_32595267.pdf
MMR scare doctor 'acted unethically', panel finds. Nick Triggle. BBC News. 2010-01-28: http://news.bbc.co.uk/2/hi/health/8483865.stm
Andrew J. Wakefield, John Walker-Smith, and Simon Murch: General Medical Council Fitness to Practice Panel Hearing 28 January 2010: http://www.circare.org/autism/gmcfpphearing_20100128.pdf
NB: Penalties, if any, are to decided at a future date by the General Medical Council.
Allegations of Misconduct Submitted to the General Medical Council re: Unethical Research on Autistic Children Conducted by Andrew J. Wakefield, John Walker-Smith, and Simon Murch. 2004-02-25: http://www.circare.org/autism/gmcallegations_20040225.pdf (6)
Comment: This document is troubling for several reasons, not the least of which is the apparent breach of confidentiality. Supporters of Dr. Wakefield and colleagues assert the document demonstrates a conflict of interest on the part of reporter Brian Deer, informant in the above document, and that by extension, the GMC proceeding against Dr. Wakefield and colleagues is somehow flawed or unjust. In our opinion this line of reasoning is based on several misunderstandings. First and foremost we believe journalists who report information likely to be of interest to regulator have an obligation to report these findings because, as a rule, regulatory authorities cannot evaluate a situation unless they receive a report. Generally speaking this arises from legal limits on the investigational authority of regulatory bodies. For example, many regulatory authorities can not open an investigation (solely) based on a news report. In context such limits are reasonable because, taken to extremes, it would be possible for board or council members to actively search for and report situations apparently suitable for investigation, and so prejudice themselves as objective judges to the potential or actual detriment of regulated parties.
In the U.S. there is a relatively rich tradition of regulatory action following news reports of objectionable circumstances in research, and it's quite likely the case consumers were spared from death or serious injury by the work of diligent journalists.
One common misunderstanding, and perhaps operating here, is the notion that only patients may legitimately complain to medical licensing authorities but this is simply incorrect. A good example of why this is so is the case where a patient dies. If there was suspicion that the patient's death was the result of substandard care (etc.), such a case would be of interest to the licensing authority and it should be self-evident the decedent could not report it. In point of fact, in our experience with U.S. medical and osteopathic licensing boards, complaints about physicians come not just from patients and their families but also from hospitals, health care workers, (rarely) federal agencies, and insurance companies. In some states licensing boards review malpractice cases and at the board's discretion may recommend investigation. In the document at issue the GMC indicated it received complaints from several sources in addition to Mr. Deer.
Another issue appears to be some lack of understanding of the way in which regulatory authorities handle complaints. As we stress on our web page on complaints about research consumers should not be afraid ofgetting somebody into troubleby complaining or asking questions. Properly speaking, complaints are allegations. In this case, the GMC, like most regulatory authorities, evaluated an allegation and determined an investigation was warranted. Based upon the results of its investigation, a decision was made to charge Dr. Wakefield and colleagues. We should also keep in mind the hearing panel has yet to render a decision, and accordingly Dr. Wakefield and his colleagues are innocent unless and until proven otherwise.
Our most serious concern about the release of this document is that it may tend to dissuade research subjects from complaining to the regulator for fear of breach of confidentiality or retribution. Consumers should keep in mind that an allegation of noncompliance is not the same thing as a finding or judgment by the regulator, and that an allegation is but the first step in a long process. More to the point, in our experience, such a breach of confidentiality is virtually unheard of and hopefully will remain this way. while supporters of Dr. Wakefield surely prefer that charges had not been filed by the GMC, in our opinion it's not correct that Mr. Deer was solely and entirely responsible for the charges, and we believe that all reporters have an obligation to report concerns arising from their work to the appropriate regulator where warranted by their professional judgment. The bottom line is that research is everyone's business, and all the more so in the absence of effective regulation to protect research subjects.
Fitness to Practise Panels week commencing 09 July 2007. Dr Andrew WAKEFIELD, Professor John WALKER-SMITH, Professor Simon MURCH. General Medical Council Press Release. 2007-07-02. Accessed on 2007-07-08 at: http://www.gmcpressoffice.org.uk/apps/news/latest/detail.php?key=345
Andrew Wakefield, John Walker-Smith, Simon Murch. General Medical Council Fitness to Practice Panel, Charge Sheet. 2007-07-16: http://www.circare.org/consents/wakefield_20070716.pdf
Statutory Instrument 2004 No. 1031 The Medicines for Human Use (Clinical Trials) Regulations 2004 (=Directive 2001/20/EC). Available from http://www.opsi.gov.uk/si/si2004/20041031.htm. Accessibility verified 2006-09-20.
UK Research Policy: International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use Guideline for Good Clinical Practice (ICH): http://www.ich.org/LOB/media/MEDIA482.pdf
UK Ethical Principles in Human Research: World Medical Association Declaration of Helsinki (2004): http://www.wma.net/e/policy/b3.htm
Central Office for Research Ethics Committees (COREC) and United Kingdom Ethics Committee Authority (UKECA): http://www.corec.org.uk/applicants/contacts/recsrecognized.htm
House of Commons Hansard Debates for 15 Mar 2004 (pt 34). MMR Vaccinations and Autism. [Dr. Evan Harris (Oxford, West and Abingdon) (LD)] Accessed on 2007-07-25 at: http://www.publications.parliament.uk/pa/cm200304/cmhansrd/vo040315/debtext/40315-34.htm#40315-34_head1
Mumps, Measles and Rubella (MMR) Vaccines and Measles Rubella (MR) Vaccines Fact Sheet (Dawbarn's Fact Sheet) Rev. 1997-06-03. Accessed on 2007-08-20 at: http://web.archive.org/web/20010718143811/http://www.whale.to/vaccines/dawbarns.html
Dawbarn's MMR Newsletter Spring 1997. Accessed on 2007-08-20 at: http://briandeer.com/wakefield/dawbarns-news.htm
(Dawbarn's) MMR and MR Vaccines Newsletter No. 4. 1996-06-10. Accessed on 2007-08-20 at: http://briandeer.com/wakefield/dawbarns-mailing.htm
H.R. (on the application of) v The Legal Services Commission  EWCA Civ 155 (28 February 2006). Accessed on 2009-04-04 at: http://www.bailii.org/ew/cases/EWCA/Civ/2006/155.html
United States Court of Federal Claims Omnibus Autism Proceeding. Accessed on 2009-04-04 at: http://www.uscfc.uscourts.gov/omnibus-autism-proceeding
United States Court of Federal Claims MMR Test Cases Index of digital audio files and transcripts (Cedillo, Hazlehurst, and Synder). Accessed on 2009-04-04 at: ftp://autism.uscfc.uscourts.gov/autism/index.html
United States Court of Federal Claims Thimerosal/Autism Test Trial Index. 2008-05-12 to 30. Accessed on 2009-04-04 at: ftp://autism.uscfc.uscourts.gov/autism/thimerosal.html
United States Court of Federal Claims Docket of Omnibus Autism Proceeding. 2002 - Accessed on 2009-04-04 at: http://www.uscfc.uscourts.gov/node/2718
United States Court of Federal Autism Decisions and Background Information. Accessed on 2009-04-04 at: http://www.uscfc.uscourts.gov/node/5026
Stephen B. Edelson. Civil No. 01CV02656. USDC Northern District of GA (Atlanta). 2001-10-04: http://www.quackwatch.org/11Ind/edelsonsuit.html
Stephen B. Edelson. Civil No. 04CV02876. USDC Northern District of GA (Atlanta). 2004-09-30: http://www.circare.org/lex/04cv02876_20040930.pdf
Stephen B. Edelson. Civil No. 2002CV63276. Superior Court of Fulton County, GA. 2002-12-23: http://www.quackwatch.org/11Ind/edelsonsuit2.html
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998;351:637-641. Accessed on 2007-08-01 at: http://tinyurl.com/3y3fmq
Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S, O'Leary JJ, Berelowitz M, Walker-Smith JA. Enterocolitis in children with developmental disorders. Am J Gastroenterol 2000;95(9):2285-2295. Accessed on 2007-08-01 at: http://tinyurl.com/2o8slj
Furlano RI, Anthony A, Day R, Brown A, McGarvey L, Thomson MA, Davies SE, Berelowitz M, Forbes A, Wakewfield AJ, Walker-Smith AJ, Murch SH. Colonic CD8 and &gamma &delta T-cell infiltration with epithelial damage in children with autism. 2001 Accessed on 2007-08-01 at: http://tinyurl.com/3dfyu8
Bradstreet JJ, El Dahr J, Anthony A, Kartzinel JJ, Wakefield AJ. Detection of measles virus genomic RNA in cerebrospinal fluid of three children with regressive autism: a report of three cases. Journal of American Physicians and Surgeons 2004;9(2):38-45. Accessed on 2007-08-01 at: http://tinyurl.com/3d7p6g
Uhlmann V, Martin CM, Sheils O, Pilkington L, Silva I, Killalea A, Murch SB, Wakefield AJ, O'Leary JJ. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol 2002;55:0-6. Accessed on 2007-08-01 at: http://tinyurl.com/2vacjs
Torrente F, Ashwood P, Day R, Machado N, Furlano RI, Anthony A, Davies SE, Wakefield AJ, Thomson MA, Walker-Smith JA, Murch SH. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psych 2002 Accessed on 2007-08-01 at: http://tinyurl.com/392wny
Wakefield AJ, Ashwood P, Limb K, Anthony A. The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. European Journal of Gastroenterology and Hepatology. 2005;17:627-638. Accessed on 2007-08-01 at: http://tinyurl.com/3yux4x
Serial No. 106-180. Autism: Present Challenges, Future Needs — Why the Increased Rates? Committee on Government Reform and Oversight. House of Representatives. 106th Congress, Second Session. April 6, 2000: http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=106_house_hearings&docid=f:69622.pdf [File size: 17.3M]
Witnesses: AJ Wakefield, John O'Leary, Walter Spitzer, Bernard Rimland, Michael Goldberg, Mary Megson, John Upledger, Vijendra Singh, Kenneth Curtis, James Smythe, Shelley Reynolds, Jeana Smith, Scott Bono, Wayne Dankner, Cathy Pratt, Deborah Hirtz, Edwin Cook, Jr., Colleen Boyle, Benjamin Schwartz, Paul Offit, Brent Taylor.
Serial No. 107-29. Autism — Why the Increased Rates? A One-Year Update. Committee on Government Reform and Oversight. House of Representatives. 107th Congress, First Session. April 25 and 26, 2001. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:76856.pdf [File size: 10.5M]
Witnesses: AJ Wakefield, Jeffrey Bradstreet, Cindy Schneider, Jeff Segal, Sharon Humiston, Walter Spitzer, Boyd Haley, David Amaral, Marie McCormick, Christopher McDougle, Elizabeth Miller, Michael Gershon, Owen Rennert, Karen Midthun, Susan Ellenberg, Norman Baylor, Colleen Boyle.
Serial No. 107-121. The Status of Research into Vaccine Safety and Autism. Committee on Government Reform and Oversight. House of Representatives. 107th Congress, Second Session. June 19, 2002. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:82358.pdf [File size: 16.2M]
Witnesses: AJ Wakefield, Jeffrey Bradstreet, Vera Stejskal, Arthur Krigsman, Frank DeStephano, Robert Chen, Roger Bernier, Stephen Foote, William Egan.
Serial No. 107-153. Vaccines and the Autism Epidemic: Reviewing the Federal Government's Track Record and Charting a Course for the Future. Committee on Government Reform and Oversight. House of Representatives. 107th Congress, Second Session. December 10, 2002. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:84605.pdf [File size: 15M]
Witnesses: Mark Geier, Walter Spitzer, David Baskin, Karen Midthun, Stephen Foote, Christopher Portier.
Also of Interest
(Ground zero: mercury
toxicity from dental amalgam morphs into thimerosal-induced autism) Serial No. 106-232. Mercury in Medicine — Are We Taking Unnecessary Risks? Committee on Government Reform and Oversight. House of Representatives. 106th Congress, Second Session. July 18, 2000. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=106_house_hearings&docid=f:72722.pdf [File size: 32M]
Witnesses: Lyn Redwood, Sallie Bernard, Albert Enyati, Elizabeth Birt, Stephanie Cave, Amy Holmes (statement), Vasken Aposhian, Sharon Humiston, Ramona Trovato, William Egan, Roger Bernier, Marie Bristol-Power.
Serial No. 107-74. The Autism Epidemic — Is the NIH and CDC Response Adequate? Committee on Government Reform and Oversight. House of Representatives. 107th Congress, Second Session. April 18, 2002. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=107_house_hearings&docid=f:80356.pdf [File size: 4.1M]
Witnesses: Lee Grossman, Belinda Lerner, Stephen Shore, Doug Compton, Colleen Boyle, Melinda Wharton, Stephen Foote, Ann Willoughby.
(How de-licensed physician Steven Edelson cures autism: $80,000 for two kids) Serial No. 108-125. The Future Challenges of Autism: A Survey of the Ongoing Initiatives in the Federal Government to Address the Epidemic. Committee on Government Reform and Oversight. House of Representatives. 108th Congress, First Session. November 20, 2003. Available from http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=108_house_hearings&docid=f:92727.pdf [File size: 1.5M]
Witnesses: Ilene Schwartz, Peter van Dyck, Rick Rollens, Steven Edelson, Colleen Pettinati.
(How hyperbaric oxygen treatment and chelation cure autism) Serial No. 108-192. Autism Spectrum Disorders: An Update of Federal Government Initiatives and Revolutionary New Treatment of Neuro-Developmental Diseases. Committee on Government Reform and Oversight. House of Representatives. 108th Congress, Second Session. May 6, 2004. Accessed on 2009-04-04 at: http://www.access.gpo.gov/congress/house/pdf/108hrg/95740.pdf [File size: 4.6M]
Witnesses: Rashid Buttar, Paul Harch, Kenneth Stoller, Julie Gordon, Shannon Kentiz, Troy Justesen.
Serial No. 108-262. Truth Revealed: New Scientific Discoveries Regarding Mercury in Medicine and Autism. Committee on Government Reform and Oversight. House of Representatives. 108th Congress, Second Session. September 8, 2004. Accessed on 2009-04-04 at: http://www.access.gpo.gov/congress/house/pdf/108hrg/98046.pdf [File size: 14M]
Witnesses: Richard Deth, Richard Fischer, Lyn Redwood, Mady Hornig, William Egan, Marcel Just, Melinda Warton, Colleen Boyle.
Vaccine row parents made to pay for son's diagnosis. Celia Hall. The Telegraph. 1999-06-02. Accessed on 2007-08-20 at: http://www.whale.to/vaccines/mmr13.html
Parents' Fury Over 'Betrayal' of Autistic Boy. Lorraine Fraser. The Telegraph. (Undated) Accessed on 2007-08-20 at: http://www.whale.to/v/mmr44.html
MMR RIP? Robert Sandall. The Sunday Times. 2003-12-14. Accessed on 2007-06-09 at: http://www.timesonline.co.uk/tol/life_and_style/article1042597.ece
BBC News | In Depth | MMR Debate. 2006-06-27. Accessed on 2007-08-20 at: http://news.bbc.co.uk/2/hi/in_depth/health/2002/mmr_debate/default.stm
£500,000 for boy left fighting for life after being used as MMR guinea pig Rachel Ellis. The Daily Mail. 2007-12-08: http://www.dailymail.co.uk/health/article-500611/500-000-boy-left-fighting-life-used-MMR-guinea-pig.html
MMR doctor admits ethics failing. BBC News. 2008-04-11.
Doctor in MMR row defends stance at disciplinary hearing. Karen McVeigh. The Guardian. 2008-03-28.
MMR scare doctor: Wakefield earned £150 an hour from law firm that planned to sue vaccine's manufacturer. Dan Newling. Daily Mail. 2008-03-28.
Doctor who sparked MMR debate defends his claims at GMC hearing. Claire Truscott. The Guardian. 2008-03-27.
The doctor who sparked the MMR vaccination debate. David Batty. The Guardian. 2008-03-27.
MMR doctor defends his research. BBC News. 2008-03-27.
MMR: Moment of truth for man behind the scare. Jeremy Laurance. The Independent. 2008-03-27.
£500,000 for boy left fighting for life after being used as MMR guinea pig Rachel Ellis. The Daily Mail. 2007-12-08.
The MMR-autism scare — our story so far. Brian Deer. Accessed on 2007-07-25 at: http://briandeer.com/mmr/lancet-summary.htm
Brian Deer's MMR Investigation. Accessed on 2009-04-04 at: http://briandeer.com/solved/solved.htm
MMR doctor Andrew Wakefield fixed data on autism. Brian Deer. The Times Online. 2009-02-08.
Hidden records show MMR truth. Brian Deer. The Times Online. 2009-02-08.
The MMR-autism theory? There's nothing in it. Michael Fitzpatrick. Spiked Online. 2007-07-04. Accessed on 2007-07-08 at: http://www.spiked-online.com/index.php?/site/article/3562/
1. Brian Deer. Briandeer.com web site. Accessed on 2007-02-07 at: http://briandeer.com/wakefield/protocol-1996.htm
2. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-11.htm
3. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-8.htm
4. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-9.htm
5. Brian Deer. Briandeer.com web site. Accessed on 2007-07-31 at: http://briandeer.com/mmr/royal-free-10.htm
Last Updated: 2011-06-28
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