Suspended Gene Therapy Test Had Drawn Early Questions. Rick Weiss. Washington Post. 2007-07-28.
URL: http://www.washingtonpost.com/wp-dyn/content/article/2007/07/27/AR2007072702242.html (Requires free registration.)
Patient in Gene Therapy Study Dies. Rick Weiss. Washington Post. 2007-07-27.
URL: http://www.washingtonpost.com/wp-dyn/content/article/2007/07/27/AR2007072700226.html (Requires free registration.)
Patient in Experimental Gene Therapy Study Dies, F.D.A. Says, Denise Grady and Andrew Pollack. The New York Times. 2007-07-27.
URL: http://www.nytimes.com/2007/07/27/health/27gene.html (Requires free registration.)
FDA Statement on Gene Therapy Clinical Trial. FDA Press Release. 2007-07-26. Accessed on 2007-07-27 at: http://www.fda.gov/bbs/topics/NEWS/2007/NEW01672.html
Related: Consent Form, TG 13G01 A Phase 1/2 Study of Repeat Intra-Articular Administration of tgAAC94, a Recombinant Adeno-Associated Vector Containing the TNFR:Fe Fusion Gene, in Inflammatory Arthritis Subjects with and without Concurrent TNF-alpha Antagonists. Sponsor: Targeted Genetics Corporation. 2006-05-08: http://www.circare.org/consents/consentform_13G01_20060508.pdf
Study of Intra-Articular Delivery of tgAAC94 in Inflammatory Arthritis Subjects. ClinicalTrials.Gov Identifier: NCT00126724. Study ID Numbers: 13G01; NIH Protocol Number: 0504-705. Last updated: 2007-05-24. Accessed on 2007-07-27 at: http://www.clinicaltrials.gov/ct/show/NCT00126724?order=2
(MAC: must use Safari) Gene Transfer Protocol Report. Study Title: A Phase 1 Dose Escalation Study of Repeat Intra-Articular Administration of tgAAC94, a Recombinant Adeno-Associated Vector Containing the TNFR:Fc Fusion Gene, in Inflammatory Arthritis Subjects with and without Concurrent TNF-α Antagonists. Protocol Number: 0504-705 [Targeted Genetics Corporation, Protocol Number 13G01]. Status as of 2006-10-05: Active. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Contents/GC_CLIN_TRIAL_RPT_VIEW.asp?WIN_TYPE=R&CTID=705
Protocol Number 0504-705 Scientific Abstract Link. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Abstracts/705_s.pdf
Protocol Number 0504-705 Non-technical Abstract Link. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Abstracts/705_nt.pdf
Gene Transfer Protocol Report. Study Title: A Phase I Dose Escalation Study of Intra-Articular Administration of tgAAC94, a Recombinant Adeno-Associated Vector Containing the TNFR:Fc Fusion Gene, in Inflammatory Arthritis. Protocol Number: 0307-588 [Targeted Genetics Corporation, Protocol Number 13E04]. Status as of 2005-05-13: No longer active. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Contents/GC_CLIN_TRIAL_RPT_VIEW.asp?WIN_TYPE=R&CTID=589
Protocol Number 0307-588 Scientific Abstract Link. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Abstracts/588_s.pdf
Protocol Number 0307-588 Non-technical Abstract Link. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Abstracts/588_nt.pdf
NIH Recombinant DNA Advisory Committee Public Review. 2003-09-17. Accessed on 2007-07-27 at: http://www4.od.nih.gov/oba/RAC/minutes/Sept_2003_Minutes.pdf
Genetic Modification Clinical Research Information System (GeMCRIS) Gene Transfer Protocol Advanced Search. Accessed on 2007-07-27 at: http://www.gemcris.od.nih.gov/Contents/GC_CT_RPT_MAKER.asp
Recombinant DNA Advisory Committee (RAC) Documents. Accessed on 2007-07-27 at: http://www4.od.nih.gov/oba/rac/documents1.htm
Recombinant DNA Advisory Committee (RAC) Protocol List. Accessed on 2007-07-27 at: http://www4.od.nih.gov/oba/rac/PROTOCOL.pdf
Targeted Genetics Provides Update on Inflammatory Arthritis Phase I/II Trial. Targeted Genetics Corporation Press Release. 2007-07-26. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle&ID=1032343&highlight=
Targeted Genetics' Inflammatory Arthritis Phase I/II Trial Placed on Clinical Hold. Targeted Genetics Corporation Press Release. 2007-07-24. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle&ID=1030172&highlight=
Targeted Genetics Amends tgAAC94 Clinical Protocol and Advances Ongoing Trial to Phase I/II; Amendment Potentially Accelerates Clinical Development Of Therapy. Targeted Genetics Corporation Press Release. 2006-03-16. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle_print&ID=832420&highlight=
Encouraging Interim Results from a Phase I/II Trial of Targeted Genetics' tgAAC94 in Patients with Inflammatory Arthritis. Targeted Genetics Corporation Press Release. 2006-06-05. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle_print&ID=871603&highlight=
Interim Data on Use of tgAAC94 in the Treatment of Inflammatory Arthritis Presented at the European Rheumatology Meeting (EULAR); Results provide preliminary evidence for sustained improvements in signs and symptoms of disease. Targeted Genetics Corporation Press Release. 2006-06-22. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle_print&ID=875154&highlight=
Targeted Genetics Initiates Next Clinical Trial of tgAAC94 in Inflammatory Arthritis. Targeted Genetics Corporation Press Release. 2005-10-11. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle&ID=766183&highlight=
Targeted Genetics Announces Preliminary Results of Phase I Clinical Trial of tgAAC94 in Patients With Inflammatory Arthritis. Targeted Genetics Corporation Press Release. 2005-07-26. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle&ID=734830&highlight=
Targeted Genetics Receives Approval to Begin Clinical Trial of tgAAC94 in Rheumatoid Arthritis. Targeted Genetics Corporation Press Release. 2004-01-20. Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-newsArticle&ID=485993&highlight=
Targeted Genetics Corporation Press Release Index (2003-2007). Accessed on 2007-07-27 at: http://ir.targen.com/phoenix.zhtml?c=84981&p=irol-news&nyo=0
Targeted Genetics Corporation. Accessed on 2007-07-27 at: http://www.targen.com/fmdwebframework/publish/publish.aspx?Page=default&Template=HomePage
The Observer and autism: a clarification. The Observer. 2007-07-22.
URL: http://observer.guardian.co.uk/comment/story/0,,2131994,00.html
Misconduct hearing starts in Britain. Daniel Cressey. Nature. 2007-07-18.
URL: http://www.nature.com/news/2007/070716/full/070716-6.html
Doctor at centre of MMR controversy accused of paying children at party for blood samples. Sarah Boseley. The Guardian. 2007-07-17.
URL: http://www.guardian.co.uk/frontpage/story/0,,2128151,00.html
MMR scare doctor 'paid children'. BBC News. 2007-07-16.
URL: http://news.bbc.co.uk/2/hi/health/6289166.stm
MMR doctor on misconduct charges. BBC News. 2007-07-16.
URL: http://news.bbc.co.uk/2/hi/uk_news/6900974.stm
Public health experts fear fallout from MMR hearing. Sarah Boseley. The Guardian. 2007-07-14.
URL: http://society.guardian.co.uk/health/story/0,,2126188,00.html
Autism: the truth. Anjana Ahuja. The Times. 2007-07-12.
URL: http://www.timesonline.co.uk/tol/life_and_style/health/article2060575.ece
Baby deaths doctor cleared. BBC News. 2007-07-11.
URL: http://news.bbc.co.uk/2/hi/uk_news/scotland/north_east/6291224.stm
Surgeon General Sees 4-Year Term as Compromised. Gardiner Harris. The New York Times. 2007-07-11.
URL: http://www.nytimes.com/2007/07/11/washington/11surgeon.html?_r=1&ref=health&oref=slogin (Requires free registration.)
Ex-director of UCLA cadaver program gets plea deal. Stuart Silverstein. Los Angeles Times. 2007-07-11.
URL: http://www.latimes.com/features/health/medicine/la-me-body11jul11,1,2930955.story?coll=la-health-medicine (Requires free registration.)
Parents of autistic boy who died sue local doctor. Associated Press / Pittsburgh Tribune-Review. 2007-07-09.
URL: http://www.pittsburghlive.com/x/pittsburghtrib/news/breaking/s_516428.html
Companies run trials of drugs they invest in. Kris Hundley. St. Petersburgh Times. 2007-07-01.
URL: http://www.sptimes.com/2007/07/01/Worldandnation/Companies_run_trials_.shtml
The MMR-autism theory? There's nothing in it.
Michael Fitzpatrick. Spiked Online. 2007-07-04.
URL: http://www.spiked-online.com/index.php?/site/article/3562/
Fitness to Practise Panels week commencing 09 July 2007. Dr Andrew Wakefield, Professor John Walker-Smith, Professor Simon Murch. General Medical Council Press Release. 2007-07-02. Accessed on 2007-07-08 at: http://www.gmcpressoffice.org.uk/apps/news/latest/detail.php?key=345
Andrew Wakefield, John Walker-Smith, Simon Murch. General Medical Council Fitness to Practice Panel, Charge Sheet. 2007-07-16: http://www.circare.org/consents/wakefield_20070716.pdf
Last Updated: 2007-09-13
If you find the information on this page helpful please support CIRCARE with a tax-deductible contribution today. Because CIRCARE doesn't accept funds from pharmaceutical or medical device manufacturers, we depend on contributions from individuals like you to help us advocate for meaningful protection of human subjects in research. Donating on-line with PayPal is quick and easy. Find out more on our Support page.
All material on this site © CIRCARE Incorporated (2002-2005) or as indicated. Single copies can be downloaded for personal education. Adobe® Reader :: ::
